BloodSafe Program Practice Test

Transfusion-related acute lung injury (TRALI) is a serious complication associated with blood transfusions, particularly platelet transfusions. TRALI occurs when antibodies in the donor plasma react with the recipient's white blood cells, leading to acute lung inflammation and respiratory distress. This reaction typically manifests within six hours of transfusion and can result in significant morbidity.

Understanding TRALI is crucial for healthcare professionals involved in administering platelet transfusions, as recognizing the signs and symptoms can lead to prompt diagnosis and management. Proper identification of high-risk donors and screening protocols can help mitigate this risk, emphasizing the importance of safety measures during transfusions.

While infection transmission, fluid overload, and allergic reactions are also potential complications of transfusions, TRALI specifically stands out due to its acute onset and severity, making it essential knowledge for anyone involved in blood transfusion practices.