What is a common premedication given to patients at risk of transfusion reactions?

Antihistamines are commonly administered as premedication for patients at risk of transfusion reactions due to their ability to block histamine release, which can mitigate allergic responses that may occur during a transfusion. Transfusion reactions can range from mild allergic reactions, such as hives and itching, to more severe reactions like anaphylaxis. By taking antihistamines beforehand, the likelihood of these mild reactions is reduced, allowing for a smoother transfusion process.

Other options such as antibiotics, pain relievers, and antidepressants do not specifically address the immediate allergic responses associated with transfusion reactions. While antibiotics might be used in certain clinical situations to prevent infections, they are not a preventive measure for transfusion reactions. Pain relievers may be used for discomfort but do not prevent allergic or immune responses. Antidepressants are unrelated to physical reactions during transfusions, as they are intended to manage mood disorders rather than physiological responses to blood products.